Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity

Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity

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Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde.1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde.The structures of the titled Schiff bases were elucidated by IR Ophthalmic and 1H NMR spectral measurements.All BETA-SITOSTEROL W FISH OIL the compounds were evaluated for their analgesic activity against swiss albino mice, anti-inflammatory activity against Wister albino rats.

The compounds showed significant antibacterial activity against Staphylococcus aureus (gram-positive) bacteria and E.coli (gram-negative) bacteria.